Cuba Gooding Jr had previously held the role
Hollyoaks actor Duncan James will become the third person to play Billy Flynn in the West End production of Chicago.
The former Blue singer has been cast in the male lead, previously played by Cuba Gooding Jr and Martin Kemp.
Duncan will star opposite Alexandra Burke as Roxie Hart from September 10.
The role of Billy Flynn was previously played by Oscar-winning Gooding Jr when the new revival of the show debuted in March 2018.
EastEnders actor and Spandau Ballet bassist Martin took over from the Hollywood star in July.
Chicago is booking at the Phoenix Theatre in London until January 2019.